FPS-ZM1

CAT: 0498-bs-82952C-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82952C-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

FPS-ZM1 is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 μM) . It is able to lower levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.1,2 Can cross the BBB. In a rat model of intracerebral hemorrhage, FPS-ZM1 was able to attenuate blood-brain barrier and white matter fiber damage.3 FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1 (HMGB1) signaling.4 FPS-ZM1 has also been shown to impair breast cancer cell invasion and metastasis.5

Conjugation

Unconjugated

Buffer

Off-White solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
C3723-10	FPS-ZM1

FPS-ZM1

Alternative Products

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