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Lonidamine

CAT: 0498-bs-82922C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82922C-01Size:10 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Lonidamine was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2 These effects have been attributed to the ability of lonidamine to inhibit mitochondrially bound hexokinase (IC50 = 90 µM for aerobic glycolysis, 45 µM for anaerobic glycolysis using Ehrlich ascites tumor cells) 2. The apoptotic effects of lonidamine have also been attributed to its ability to disrupt the mitochondrial transmembrane potential3, intracellular acidification by inhibition of lactate efflux4, and inhibition of mitochondrial pyruvate (MCP) and monocarboxylate transporter (MCT) 5.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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