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POB

CAT: 0498-bs-82917C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82917C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
RT

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