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7-Cl-O-Nec1

CAT: 0498-bs-82910C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82910C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1) .3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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