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Salubrinal

CAT: 0498-bs-82890C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82890C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α) .1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
Conjugation
Unconjugated
Buffer
Beige solid
Storage Conditions
-20°C

Alternative Products

CatalogName
B2025-10Salubrinal

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