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CCT251236

CAT: 0498-bs-82859C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82859C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction) .1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2
Conjugation
Unconjugated
Buffer
Off-white/beige solid
Storage Conditions
-20°C

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BA4180-50CCT251236
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A12543-25CCT251236 25mg
A12543-50CCT251236 50mg
A12543-10CCT251236 10mg
A12543-1CCT251236 1mg
TBI4410-5MGCCT251236, HSF1 inhibitor

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