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BI01383298

CAT: 0498-bs-82817C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82817C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BI01383298 is a potent, non-competitive, irreversible inhibitor of the human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) .1,2 IC50 = 49 nM in the presence of Li+ with preincubation and 118 nM without Li+. BI01393298 is inactive in mouse NaCT for citrate transport. NaCT delivers citrate, a key metabolite and regulator of multiple biochemical pathways, from the blood to hepatocytes and neurons. Reduced expression of NaCT has been linked to longevity and increased expression has been linked to type 2 diabetes and non-alcoholic fatty liver disease. BI01383298 also blocked transport of arginine, dimethylarginine, and L-homoarginine in both human and mouse NaCT.2
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
564050BI01383298
A18831-100BI01383298 100mg
A18831-50BI01383298 50mg
A18831-25BI01383298 25mg
A18831-10BI01383298 10mg
A18831-5BI01383298 5mg
A18831-200BI01383298 200mg
TBI4191-25MGBI01383298, Citrate transporter inhibitor
A18831-10mM-DBI01383298 10mM * 1mL in DMSO

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