Products for Research Use Only
RegisterLogin

GSK2830371

CAT: 0498-bs-82816C-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-82816C-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma2, acute myeloid leukemia3, and breast4. It enhances phosphorylation of the tumor suppressor p53 leading to activation.5,6
Conjugation
Unconjugated
Buffer
Tan solid
Storage Conditions
-20°C

Alternative Products

CatalogName
C12787-50mgGSK2830371
TBI4180-25MGGSK2830371, WIP1 phosphatase inhibitor

Popular Products