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RU.521

CAT: 0498-bs-82809C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82809C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
Conjugation
Unconjugated
Buffer
Off-white to pale pink solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
OR1023263-01RU-521
BUP04909-01RU.521
MBS3843271-01RU.521 (RU320521)
TBI4140-5MGRU.521, cGAS inhibitor
A18811-1RU.521 (RU320521) 1mg
A18811-10RU.521 (RU320521) 10mg
A18811-50RU.521 (RU320521) 50mg
A18811-100RU.521 (RU320521) 100mg
A18811-2RU.521 (RU320521) 2mg
A18811-5RU.521 (RU320521) 5mg

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