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P22077

CAT: 0498-bs-82805C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82805C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
P22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2 P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis.3 N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4 It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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C12467-50mgP22077
TBI4125-10MGP22077, USP7 inhibitor
217330DUB Inhibitor VI, P22077 (1- (5- (2,4-Difluorophenylthio) -4-nitrothiophen-2-yl) ethanone, USP7 Inhibitor II, USP47 Inhibitor II)

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