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Galunisertib

CAT: 0498-bs-82796C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82796C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Galunisertib is a TGF-B kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in clinical trials for treatment of various cancers.3-5 Galunisertib has more recently been used to enhance the anti-neuroblastoma activity of anti-GD2 antibody Dinutuximab with natural killer cells6 and preserved the function of in vitro expanded natural killer cells in AML and colon cancer models7. Galunisertib reversed TGF and regulatory T cell mediated suppression of human T cell proliferation. In combination with PD-L1 blockade, it resulted in improved tumor growth inhibition and complete regressions in colon carcinoma models.8
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

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HY-13226-01Galunisertib
S2230-10mM/1mLGalunisertib (LY2157299)
HY-13226R-01Galunisertib (Standard)
GTR19212490-01Galunisertib Monohydrate
HY-13226AGalunisertib (monohydrate)

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