TIC10

• Background:

  TIC10 (1616632-77-9) is novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell death.1-3 TIC10 potently activates mitochondrial caseinolytic protease P (ClpP) causing eIF2-independent induction of ATF4 and Akt/ERK/Foxo3a/DR5/TRAIL-dependent apoptosis.4 Currently in clinical trials.

• Conjugation:

  Unconjugated

• Buffer:

  Pale yellow solid

• Storage Conditions:

  -20°C