A-196
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
A-196
Background :
A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1 (IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM) . It substantially inhibited non-homologous end-joining (NHEJ) -directed DNA repair but not homology-directed repair (HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.Conjugation :
UnconjugatedBuffer :
White solidStorage Conditions :
-20°C
