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URMC-099

CAT: 0498-bs-82755C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82755C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
URMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3) . It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM) .1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid- degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

Alternative Products

CatalogName
B4877-5.1URMC-099
FU170951-01URMC 099

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