Grapiprant

CAT: 0498-bs-82750C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82750C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5

Conjugation

Unconjugated

Buffer

Off-white solid

Storage Conditions

-20°C

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Grapiprant

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