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ML382

CAT: 0498-bs-82737C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82737C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
562786ML382
A22168-200ML382 200mg
A22168-50ML382 50mg
A22168-25ML382 25mg
A22168-10ML382 10mg
A22168-100ML382 100mg
A22168-5ML382 5mg
A22168-10mM-DML382 10mM * 1mL in DMSO
TBI3937-10MGML382, MRGPRX1 positive allosteric modulator

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