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SJ6986

CAT: 0498-bs-82734C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82734C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2) .1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos) . SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-132199-01SJ6986
TBI3933-5MGSJ6986, GSPT1 molecular glue

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