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DJ001

CAT: 0498-bs-82713C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82713C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP) IC50=1.54 M and >10 M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

Alternative Products

CatalogName
BA3034-50DJ001
TBI3800-5MGDJ001, PTPσ inhibitor

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