IMR-1

• Background :

  Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay) . IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay) . Binding of IMR-1 to NTC is non-covalent and reversible.1

• Conjugation :

  Unconjugated

• Buffer :

  Yellow solid

• Storage Conditions :

  -20°C