IMR-1

CAT: 0498-bs-82696C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82696C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay) . IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay) . Binding of IMR-1 to NTC is non-covalent and reversible.1
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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