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Verrucarin A

CAT: 0498-bs-82691CSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82691CSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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