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CLP-3094

CAT: 0498-bs-82670C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82670C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR1391. Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine2. CLP-3094 was identified as a potent and selective GPR142 antagonist with an IC50=2.3 M against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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