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PAC-1

CAT: 0498-bs-82621C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82621C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2 Sensitizes cancer cells to various chemotherapeutic agents.3
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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A8177-SPAC-1
FP15826-01PAC 1

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