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Embelin

CAT: 0498-bs-82619C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82619C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM) . Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide) . Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.
Conjugation
Unconjugated
Buffer
Dark orange solid
Storage Conditions
-20°C

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CatalogName
A8235-5.1Embelin

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