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Pomalidomide

CAT: 0498-bs-82578C-01Size: 20 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82578C-01Size:20 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-10984-01Pomalidomide

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