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NSC23766

CAT: 0498-bs-82568C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82568C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NSC-23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
RT

Alternative Products

CatalogName
GTR19304111-01NSC23766
A1952-100NSC23766 trihydrochloride
029597-01Rac1 Inhibitor (NSC23766)
510327NSC23766 3HCl salt

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