Chymostatin

• Background:

  A potent, competitive, slow-binding inhibitor of α-, β-, γ-, δ-chymotrypsin, papain and cathepsins B/G (chymotryptase-like serine proteases) 1, Ki=9.36 and 13.1 nM for chymotrypsin and chymase2. Cathepsin G Ki=0.15 μM.3 Consists of a mixture of type A (L-Leu), B (L-Val) and C (L-Ile) forms.1 Decreases plasma and tissue levels of angiotensin II without lowering mean blood pressure in a hypertensive rat model.4 Commonly used in lysis buffers to prevent degradation of proteins. Typical working concentration is 6-60 µg/ml.

• Conjugation:

  Unconjugated

• Buffer:

  White or off-white solid

• Storage Conditions:

  -20°C