AS-605240

• Background:

  Potent and selective inhibitor of PI 3-kinase  (PI 3-K), IC50 = 8 nM displaying 30-fold selectivity over PI 3-K and PI 3-K and 7.5-fold selectivity over PI 3-K1. Suppresses joint inflammation in two distinct mouse models1. Ameliorates surgical brain injury2, colitis3, intimal hyperplasia-induced inflammatory processes4 and renal injury/fibrosis5 in rodent models. Orally active.

• Conjugation:

  Unconjugated

• Buffer:

  Red solid

• Storage Conditions:

  -20°C