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SC-560

CAT: 0498-bs-82516C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82516C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1 (COX-1) .1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2
Conjugation
Unconjugated
Buffer
Brown solid
Storage Conditions
-20°C

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Alternative Products

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B6786-25SC 560
T4101-01SC-560
A13023-25SC 560 25mg

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