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Rocaglamide

CAT: 0498-bs-82506C-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0498-bs-82506C-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Rocaglamide is a potent inhibitor of NFkB in T-lymphocytes with almost complete inhibition at 200nM.1 It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and TNF-α production at 50nM in T-cells without inhibiting AP-1 and NF-kB (conversely, at concentrations <100nM, it was shown to increase NF-kB activity) .2 Immunosuppression activity was due to inhibition of cytokine gene expression via blocking of NF-AT activity and is a different mechanism than suppression via Cyclosporine a and FK-506. Rocaglamide has anti-cancer properties via various pathways including ERK inhibition3, ATM/ATR-Chk1/Chk2 activation4, and p38 and JNK activation5.
Conjugation
Unconjugated
Buffer
White solid - presented as thin film on glass vial
Storage Conditions
-20°C

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CatalogName
MBS6062694-01Rocaglamide (Rocaglamide A)
CS-BT-00549Rocaglamide
TQ0131L-01(+) -Rocaglamide

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