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SN-38

CAT: 0498-bs-82487C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82487C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively) . Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively) .
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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2684/10SN 38

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