Leflunomide

• Background :

  A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug) 1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) 2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury3.

• Conjugation :

  Unconjugated

• Buffer :

  White solid

• Storage Conditions :

  RT