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Pirfenidone

CAT: 0498-bs-82463C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82463C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action.3 Inhibits fibroblast proliferation.4 Suppresses TNFα production at the translational level.5 Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner.6 Recently approved therapeutic agent for idiopathic pulmonary fibrosis.7 Orally active.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
RT

Alternative Products

CatalogName
B2288-5.1Pirfenidone

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