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Vismodegib

CAT: 0498-bs-82427C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82427C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM) .1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2 Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 μM respectively.3 Clinically useful for the treatment of basal cell carcinoma.4 Inhibits proliferation and induces apoptosis in colon cancer cell lines.
Conjugation
Unconjugated
Buffer
Off-white or beige solid
Storage Conditions
-20°C

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CS-O-15648Vismodegib M3
HY-W705354-01Vismodegib-d4

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