VX-702

• Background:

  A potent and selective inhibitor of p38 MAP kinases, p38 MAPK and p38 (KD = 3.7 and 17 nM respectively) .1 Inhibits IL-6, IL-1 and TNF production in LPS-primed blood.1 Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 M.2 Provides only modest clinical efficacy in rheumatoid arthritis.3,4 Delays platelet lesions and leads to better maintenance of stored platelets.5

• Conjugation:

  Unconjugated

• Buffer:

  White solid

• Storage Conditions:

  -20°C