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Dovitinib

CAT: 0498-bs-82404C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82404C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM) .1 Active in cell culture and in whole animals. Selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
Conjugation
Unconjugated
Buffer
Yellow-green solid
Storage Conditions
-20°C

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