Bexarotene

• Background:

  A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively) 1. Clinically useful antineoplastic agent for cutaneous T-cell lymphoma2 Causes complete regression of mammary carcinoma3. Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability4. Reverses apoE4-driven brain pathology and behavioral deficits in vivo5.

• Conjugation:

  Unconjugated

• Buffer:

  White solid

• Storage Conditions:

  -20°C