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CD261 Antibody

CAT: 0013-GTR17857369Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR17857369Size:0.1 mg
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Description
Mouse monoclonal antibody to CD261 which is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to activated CD261 which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety oFT tumour-derived cell lines. It plays a role in inducing cell death. The binding oFT TRAIL to DR4 triggers the activation oFT pro-caspases 8 and 10, leading to apoptosis.
Product Name Alternative
DR4, APO2, TNFRSF10A, TRAILR1, TRAIL-R1
UniProt
O00220
Reactivity
Human
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Target
CD261
Clonality
Monoclonal
Clone
DR-4-02
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation; Cell Biology
Purification
Purified by protein-A affinity chromatography.
Concentration
1 mg/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Functional application: Soluble antibody DR-4-02 blocks apoptosis triggered by a ligand (TRAIL) . Plastic-immobilized (cross-linked) DR-4-02 antibody induces apoptosis in sensitive cells. Recommended dilution of antibody: 2-3 μg/ml in cultivation medium, final concentration of TRAIL: 20-200 ng/ml; it is recommended to add the antibody 15 min before addition of TRAIL. Flow cytometry: Recommended dilution: 2-4 μg/ml.
Tested Applications
FA, FC, ICC, IP
Preservative
Phosphate buffered saline (PBS), pH 7.4
Isotype
Mouse IgG1
Entrez
8797

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