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Gliotoxin

CAT: 0498-bs-82378C-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82378C-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B cells.1 Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. It inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells.5
Conjugation
Unconjugated
Buffer
White lyophilized solid
Storage Conditions
-20°C

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