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Itraconazole

CAT: 0498-bs-82362C-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82362C-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Itraconazole inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme1. Clinically useful antifungal agent. It inhibits the proliferation of glioblastoma cells in vitro and in vivo by inducing autophagic progression via inhibiting the trafficking of cholesterol from late endosomes and lysosomes to the plasma membrane2. Inhibits the hedgehog pathway by binding to Smoothened (SMO) via a mechanism distinct from that of cyclopamine3. Inhibits angiogenesis via inhibiting the binding of VEGF to VEGFR24.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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CatalogName
C08596-200mgItraconazole

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