4μ8C

CAT: 0498-bs-82328C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82328C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM) . Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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