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Dabrafenib

CAT: 0498-bs-82325C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82325C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively) .1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

Alternative Products

CatalogName
D072-25MGDabrafenib

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