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ML241

CAT: 0498-bs-82317C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82317C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3
Conjugation
Unconjugated
Buffer
Pale yellow solid
Storage Conditions
-20°C

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MBS3841299-01ML241
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