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KU-55933

CAT: 0498-bs-82299C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82299C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5
Conjugation
Unconjugated
Buffer
Tan solid
Storage Conditions
-20°C

Alternative Products

CatalogName
A4605-SKU 55933
T2685-01KU-55933

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