HIF-2α-I2

• Background :

  Potent and selective HIF-2α inhibitor, Kd=81 nM.1 Binds to the HIF-2α PAS-B domain2 and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2

• Conjugation :

  Unconjugated

• Buffer :

  Yellow solid

• Storage Conditions :

  -20°C