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XIB4035

CAT: 0498-bs-82277C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82277C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4
Conjugation
Unconjugated
Buffer
Light brown solid
Storage Conditions
RT

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CatalogName
abx282369-01XIB4035
TBI1486-25MGXIB4035, GFRa1 agonist

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