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NSC405020

CAT: 0498-bs-82259C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82259C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity in vivo. (IC50 > 100 μM) . Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2. Suppresses bone erosion in a c-Fos-deficient mouse model.2 Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
RT

Alternative Products

CatalogName
GTR19173151-01NSC405020
217568MT1-MMP Inhibitor, NSC405020 (3,4-Dichloro-N- (1-methylbutyl) benzamide, 3,4-Dichloro-N- (pentan-2-yl) benzamide)

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