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680C91

CAT: 0498-bs-82245C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82245C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM) 1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4.
Conjugation
Unconjugated
Buffer
Light brown solid
Storage Conditions
-20°C

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