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Spautin-1

CAT: 0498-bs-82205C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82205C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable.
Conjugation
Unconjugated
Buffer
Tan solid
Storage Conditions
-20°C

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