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A83-01

CAT: 0498-bs-82179C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82179C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.
Conjugation
Unconjugated
Buffer
Light yellow solid
Storage Conditions
-20°C

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