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6-Thioguanine

CAT: 0498-bs-82152C-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82152C-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1) .2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
Conjugation
Unconjugated
Buffer
Pale yellow solid
Storage Conditions
-20°C

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